Prevalence and Health Outcomes of Functional Gastrointestinal Symptoms in Infants From Birth to 12 Months of Age
Identifieur interne : 000124 ( Main/Exploration ); précédent : 000123; suivant : 000125Prevalence and Health Outcomes of Functional Gastrointestinal Symptoms in Infants From Birth to 12 Months of Age
Auteurs : Yvan Vandenplas [Belgique] ; Abdelhak Abkari [Maroc] ; Marc Bellaiche [France] ; Marc Benninga [Pays-Bas] ; Jean Pierre Chouraqui [France] ; Fügençullu Çoku Ra [Turquie] ; Tracy Harb [Australie] ; Badriul Hegar [Indonésie] ; Carlos Lifschitz [Argentine] ; Thomas Ludwig [Pays-Bas] ; Mohamed Miqdady [Émirats arabes unis] ; Mauro Batista De Morais [Brésil] ; Seksit Osatakul [Thaïlande] ; Silvia Salvatore [Italie] ; Raanan Shamir [Israël] ; Annamaria Staiano [Italie] ; Hania Szajewska [Pologne] ; Nikhil Thapar [Royaume-Uni]Source :
- Journal of Pediatric Gastroenterology and Nutrition [ 0277-2116 ] ; 2015.
Abstract
The aim of the study was to review published evidence and the opinion of practising clinicians on the prevalence and long-term health consequences of functional gastrointestinal symptoms in infants younger than 12 months.
PubMed was searched from inception to November 2014 to find articles reporting the prevalence and long-term health outcomes of infantile colic, regurgitation, functional constipation, functional diarrhoea, and dyschezia in infants younger than <12 months. A questionnaire was sent to practising clinicians worldwide, and a group of 15 international experts met to discuss the likely frequency and longer-term consequences of these symptoms.
The literature search identified 30 studies reporting the prevalence of infantile colic (2%–73%), 13 that of regurgitation (3%–87%), 8 that of functional constipation (0.05%–39.3%), 2 that of functional diarrhoea (2%–4.1%), and 3 that of dyschezia (0.9%–5.6%). The studies varied in design, populations investigated, and definition of the symptoms. Questionnaires were received from 369 respondents. The experts agreed that the likely prevalences for colic, regurgitation, and functional constipation were 20%, 30%, and 15%, respectively. The limited data in the literature for functional diarrhoea and dyschezia suggest prevalences <10%. Infantile colic may be associated with future health problems in a subset of infants.
Functional gastrointestinal symptoms appear to occur in a significant proportion of infants younger than 12 months and may have an impact on future health outcomes. Prospective collection of data according to agreed criteria is needed to obtain more accurate estimates of the prevalence and consequences of these symptoms.
Url:
DOI: 10.1097/MPG.0000000000000949
PubMed: 26308317
PubMed Central: 4631121
Affiliations:
- Argentine, Australie, Belgique, Brésil, France, Indonésie, Israël, Italie, Maroc, Pays-Bas, Pologne, Royaume-Uni, Thaïlande, Turquie, Émirats arabes unis
- Angleterre, Grand Londres, Hollande-Septentrionale, Région de Bruxelles-Capitale, Utrecht (province), État de São Paulo
- Amsterdam, Bruxelles, Londres, Paris, São Paulo, Utrecht
- Université de São Paulo
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Le document en format XML
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Hassan 2, Casablanca, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Unit of Pediatric Gastroenterology, University Hospital Ibn Rochd, Faculty of Medicine, University Hassan 2, Casablanca</wicri:regionArea><wicri:noRegion>Casablanca</wicri:noRegion></affiliation></author><author><name sortKey="Bellaiche, Marc" sort="Bellaiche, Marc" uniqKey="Bellaiche M" first="Marc" last="Bellaiche">Marc Bellaiche</name><affiliation wicri:level="1"><nlm:aff id="aff3">GI Unit, Robert Debre Hospital, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>GI Unit, Robert Debre Hospital, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Benninga, Marc" sort="Benninga, Marc" uniqKey="Benninga M" first="Marc" last="Benninga">Marc Benninga</name><affiliation wicri:level="3"><nlm:aff id="aff4">Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Emma Children's Hospital/Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Chouraqui, Jean Pierre" sort="Chouraqui, Jean Pierre" uniqKey="Chouraqui J" first="Jean Pierre" last="Chouraqui">Jean Pierre Chouraqui</name><affiliation wicri:level="1"><nlm:aff id="aff5">Gastroentérologie, Hépatologie et Nutrition, Clinique Universitaire de Pédiatrie, Grenoble Cedex 9, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Gastroentérologie, Hépatologie et Nutrition, Clinique Universitaire de Pédiatrie, Grenoble Cedex 9</wicri:regionArea><wicri:noRegion>Grenoble Cedex 9</wicri:noRegion><wicri:noRegion>Grenoble Cedex 9</wicri:noRegion></affiliation></author><author><name sortKey="Coku Ra, Fugencullu" sort="Coku Ra, Fugencullu" uniqKey="Coku Ra F" first="Fügençullu" last="Çoku Ra">Fügençullu Çoku Ra</name><affiliation wicri:level="1"><nlm:aff id="aff6">Pediatric Gastroenterology Hepatology and Nutrition, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Pediatric Gastroenterology Hepatology and Nutrition, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Harb, Tracy" sort="Harb, Tracy" uniqKey="Harb T" first="Tracy" last="Harb">Tracy Harb</name><affiliation wicri:level="1"><nlm:aff id="aff7">Children's Nutrition Research Centre, Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Children's Nutrition Research Centre, Queensland Children's Medical Research Institute, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Hegar, Badriul" sort="Hegar, Badriul" uniqKey="Hegar B" first="Badriul" last="Hegar">Badriul Hegar</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Child Health University of Indonesia, Jakarta, Indonesia</nlm:aff><country xml:lang="fr">Indonésie</country><wicri:regionArea>Department of Child Health University of Indonesia, Jakarta</wicri:regionArea><wicri:noRegion>Jakarta</wicri:noRegion></affiliation></author><author><name sortKey="Lifschitz, Carlos" sort="Lifschitz, Carlos" uniqKey="Lifschitz C" first="Carlos" last="Lifschitz">Carlos Lifschitz</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department of Pediatrics, Section of Gastroenterology, Hepatology, and Transplantation, Hospital Italiano, Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Department of Pediatrics, Section of Gastroenterology, Hepatology, and Transplantation, Hospital Italiano, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Ludwig, Thomas" sort="Ludwig, Thomas" uniqKey="Ludwig T" first="Thomas" last="Ludwig">Thomas Ludwig</name><affiliation wicri:level="3"><nlm:aff id="aff10">Nutricia Research, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Nutricia Research, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Miqdady, Mohamed" sort="Miqdady, Mohamed" uniqKey="Miqdady M" first="Mohamed" last="Miqdady">Mohamed Miqdady</name><affiliation wicri:level="1"><nlm:aff id="aff11">Pediatric GI, Hepatology, and Nutrition, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates</nlm:aff><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Pediatric GI, Hepatology, and Nutrition, Sheikh Khalifa Medical City, Abu Dhabi</wicri:regionArea><wicri:noRegion>Abu Dhabi</wicri:noRegion></affiliation></author><author><name sortKey="De Morais, Mauro Batista" sort="De Morais, Mauro Batista" uniqKey="De Morais M" first="Mauro Batista" last="De Morais">Mauro Batista De Morais</name><affiliation wicri:level="4"><nlm:aff id="aff12">Division of Pediatric Gastroenterology, Paulista School of Medicine, Federal University of São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Pediatric Gastroenterology, Paulista School of Medicine, Federal University of São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Osatakul, Seksit" sort="Osatakul, Seksit" uniqKey="Osatakul S" first="Seksit" last="Osatakul">Seksit Osatakul</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla</wicri:regionArea><wicri:noRegion>Songkhla</wicri:noRegion></affiliation></author><author><name sortKey="Salvatore, Silvia" sort="Salvatore, Silvia" uniqKey="Salvatore S" first="Silvia" last="Salvatore">Silvia Salvatore</name><affiliation wicri:level="1"><nlm:aff id="aff14">Clinica Pediatrica, Università dell’Insubria, Varese, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Pediatrica, Università dell’Insubria, Varese</wicri:regionArea><wicri:noRegion>Varese</wicri:noRegion></affiliation></author><author><name sortKey="Shamir, Raanan" sort="Shamir, Raanan" uniqKey="Shamir R" first="Raanan" last="Shamir">Raanan Shamir</name><affiliation wicri:level="1"><nlm:aff id="aff15">Schneider Children's Medical Centre of Israel, Tel-Aviv University, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Schneider Children's Medical Centre of Israel, Tel-Aviv University</wicri:regionArea><wicri:noRegion>Tel-Aviv University</wicri:noRegion></affiliation></author><author><name sortKey="Staiano, Annamaria" sort="Staiano, Annamaria" uniqKey="Staiano A" first="Annamaria" last="Staiano">Annamaria Staiano</name><affiliation wicri:level="1"><nlm:aff id="aff16">Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Szajewska, Hania" sort="Szajewska, Hania" uniqKey="Szajewska H" first="Hania" last="Szajewska">Hania Szajewska</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Paediatrics, Medical University of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Thapar, Nikhil" sort="Thapar, Nikhil" uniqKey="Thapar N" first="Nikhil" last="Thapar">Nikhil Thapar</name><affiliation wicri:level="3"><nlm:aff id="aff18">Gastroenterology Unit, Great Ormond Street Hospital and UCL Institute of Child Health, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Gastroenterology Unit, Great Ormond Street Hospital and UCL Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26308317</idno><idno type="pmc">4631121</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631121</idno><idno type="RBID">PMC:4631121</idno><idno type="doi">10.1097/MPG.0000000000000949</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000045</idno><idno type="wicri:Area/Pmc/Curation">000045</idno><idno type="wicri:Area/Pmc/Checkpoint">000098</idno><idno type="wicri:Area/Ncbi/Merge">000338</idno><idno type="wicri:Area/Ncbi/Curation">000338</idno><idno type="wicri:Area/Ncbi/Checkpoint">000338</idno><idno type="wicri:doubleKey">0277-2116:2015:Vandenplas Y:prevalence:and:health</idno><idno type="wicri:Area/Main/Merge">000124</idno><idno type="wicri:Area/Main/Curation">000124</idno><idno type="wicri:Area/Main/Exploration">000124</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prevalence and Health Outcomes of Functional Gastrointestinal Symptoms in Infants From Birth to 12 Months of Age</title><author><name sortKey="Vandenplas, Yvan" sort="Vandenplas, Yvan" uniqKey="Vandenplas Y" first="Yvan" last="Vandenplas">Yvan Vandenplas</name><affiliation wicri:level="3"><nlm:aff id="aff1">UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>UZ Brussel, Vrije Universiteit Brussel, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Abkari, Abdelhak" sort="Abkari, Abdelhak" uniqKey="Abkari A" first="Abdelhak" last="Abkari">Abdelhak Abkari</name><affiliation wicri:level="1"><nlm:aff id="aff2">Unit of Pediatric Gastroenterology, University Hospital Ibn Rochd, Faculty of Medicine, University Hassan 2, Casablanca, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Unit of Pediatric Gastroenterology, University Hospital Ibn Rochd, Faculty of Medicine, University Hassan 2, Casablanca</wicri:regionArea><wicri:noRegion>Casablanca</wicri:noRegion></affiliation></author><author><name sortKey="Bellaiche, Marc" sort="Bellaiche, Marc" uniqKey="Bellaiche M" first="Marc" last="Bellaiche">Marc Bellaiche</name><affiliation wicri:level="1"><nlm:aff id="aff3">GI Unit, Robert Debre Hospital, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>GI Unit, Robert Debre Hospital, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Benninga, Marc" sort="Benninga, Marc" uniqKey="Benninga M" first="Marc" last="Benninga">Marc Benninga</name><affiliation wicri:level="3"><nlm:aff id="aff4">Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Emma Children's Hospital/Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Chouraqui, Jean Pierre" sort="Chouraqui, Jean Pierre" uniqKey="Chouraqui J" first="Jean Pierre" last="Chouraqui">Jean Pierre Chouraqui</name><affiliation wicri:level="1"><nlm:aff id="aff5">Gastroentérologie, Hépatologie et Nutrition, Clinique Universitaire de Pédiatrie, Grenoble Cedex 9, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Gastroentérologie, Hépatologie et Nutrition, Clinique Universitaire de Pédiatrie, Grenoble Cedex 9</wicri:regionArea><wicri:noRegion>Grenoble Cedex 9</wicri:noRegion><wicri:noRegion>Grenoble Cedex 9</wicri:noRegion></affiliation></author><author><name sortKey="Coku Ra, Fugencullu" sort="Coku Ra, Fugencullu" uniqKey="Coku Ra F" first="Fügençullu" last="Çoku Ra">Fügençullu Çoku Ra</name><affiliation wicri:level="1"><nlm:aff id="aff6">Pediatric Gastroenterology Hepatology and Nutrition, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Pediatric Gastroenterology Hepatology and Nutrition, Cerrahpaşa Medical Faculty, University of Istanbul, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Harb, Tracy" sort="Harb, Tracy" uniqKey="Harb T" first="Tracy" last="Harb">Tracy Harb</name><affiliation wicri:level="1"><nlm:aff id="aff7">Children's Nutrition Research Centre, Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Children's Nutrition Research Centre, Queensland Children's Medical Research Institute, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Hegar, Badriul" sort="Hegar, Badriul" uniqKey="Hegar B" first="Badriul" last="Hegar">Badriul Hegar</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Child Health University of Indonesia, Jakarta, Indonesia</nlm:aff><country xml:lang="fr">Indonésie</country><wicri:regionArea>Department of Child Health University of Indonesia, Jakarta</wicri:regionArea><wicri:noRegion>Jakarta</wicri:noRegion></affiliation></author><author><name sortKey="Lifschitz, Carlos" sort="Lifschitz, Carlos" uniqKey="Lifschitz C" first="Carlos" last="Lifschitz">Carlos Lifschitz</name><affiliation wicri:level="1"><nlm:aff id="aff9">Department of Pediatrics, Section of Gastroenterology, Hepatology, and Transplantation, Hospital Italiano, Buenos Aires, Argentina</nlm:aff><country xml:lang="fr">Argentine</country><wicri:regionArea>Department of Pediatrics, Section of Gastroenterology, Hepatology, and Transplantation, Hospital Italiano, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Ludwig, Thomas" sort="Ludwig, Thomas" uniqKey="Ludwig T" first="Thomas" last="Ludwig">Thomas Ludwig</name><affiliation wicri:level="3"><nlm:aff id="aff10">Nutricia Research, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Nutricia Research, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Miqdady, Mohamed" sort="Miqdady, Mohamed" uniqKey="Miqdady M" first="Mohamed" last="Miqdady">Mohamed Miqdady</name><affiliation wicri:level="1"><nlm:aff id="aff11">Pediatric GI, Hepatology, and Nutrition, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates</nlm:aff><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Pediatric GI, Hepatology, and Nutrition, Sheikh Khalifa Medical City, Abu Dhabi</wicri:regionArea><wicri:noRegion>Abu Dhabi</wicri:noRegion></affiliation></author><author><name sortKey="De Morais, Mauro Batista" sort="De Morais, Mauro Batista" uniqKey="De Morais M" first="Mauro Batista" last="De Morais">Mauro Batista De Morais</name><affiliation wicri:level="4"><nlm:aff id="aff12">Division of Pediatric Gastroenterology, Paulista School of Medicine, Federal University of São Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Division of Pediatric Gastroenterology, Paulista School of Medicine, Federal University of São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Osatakul, Seksit" sort="Osatakul, Seksit" uniqKey="Osatakul S" first="Seksit" last="Osatakul">Seksit Osatakul</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla</wicri:regionArea><wicri:noRegion>Songkhla</wicri:noRegion></affiliation></author><author><name sortKey="Salvatore, Silvia" sort="Salvatore, Silvia" uniqKey="Salvatore S" first="Silvia" last="Salvatore">Silvia Salvatore</name><affiliation wicri:level="1"><nlm:aff id="aff14">Clinica Pediatrica, Università dell’Insubria, Varese, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinica Pediatrica, Università dell’Insubria, Varese</wicri:regionArea><wicri:noRegion>Varese</wicri:noRegion></affiliation></author><author><name sortKey="Shamir, Raanan" sort="Shamir, Raanan" uniqKey="Shamir R" first="Raanan" last="Shamir">Raanan Shamir</name><affiliation wicri:level="1"><nlm:aff id="aff15">Schneider Children's Medical Centre of Israel, Tel-Aviv University, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Schneider Children's Medical Centre of Israel, Tel-Aviv University</wicri:regionArea><wicri:noRegion>Tel-Aviv University</wicri:noRegion></affiliation></author><author><name sortKey="Staiano, Annamaria" sort="Staiano, Annamaria" uniqKey="Staiano A" first="Annamaria" last="Staiano">Annamaria Staiano</name><affiliation wicri:level="1"><nlm:aff id="aff16">Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Szajewska, Hania" sort="Szajewska, Hania" uniqKey="Szajewska H" first="Hania" last="Szajewska">Hania Szajewska</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Paediatrics, Medical University of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Thapar, Nikhil" sort="Thapar, Nikhil" uniqKey="Thapar N" first="Nikhil" last="Thapar">Nikhil Thapar</name><affiliation wicri:level="3"><nlm:aff id="aff18">Gastroenterology Unit, Great Ormond Street Hospital and UCL Institute of Child Health, London, UK.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Gastroenterology Unit, Great Ormond Street Hospital and UCL Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Pediatric Gastroenterology and Nutrition</title><idno type="ISSN">0277-2116</idno><idno type="eISSN">1536-4801</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><sec><title>Objectives:</title><p>The aim of the study was to review published evidence and the opinion of practising clinicians on the prevalence and long-term health consequences of functional gastrointestinal symptoms in infants younger than 12 months.</p></sec><sec sec-type="methods"><title>Methods:</title><p>PubMed was searched from inception to November 2014 to find articles reporting the prevalence and long-term health outcomes of infantile colic, regurgitation, functional constipation, functional diarrhoea, and dyschezia in infants younger than <12 months. A questionnaire was sent to practising clinicians worldwide, and a group of 15 international experts met to discuss the likely frequency and longer-term consequences of these symptoms.</p></sec><sec sec-type="results"><title>Results:</title><p>The literature search identified 30 studies reporting the prevalence of infantile colic (2%–73%), 13 that of regurgitation (3%–87%), 8 that of functional constipation (0.05%–39.3%), 2 that of functional diarrhoea (2%–4.1%), and 3 that of dyschezia (0.9%–5.6%). The studies varied in design, populations investigated, and definition of the symptoms. Questionnaires were received from 369 respondents. The experts agreed that the likely prevalences for colic, regurgitation, and functional constipation were 20%, 30%, and 15%, respectively. The limited data in the literature for functional diarrhoea and dyschezia suggest prevalences <10%. Infantile colic may be associated with future health problems in a subset of infants.</p></sec><sec sec-type="conclusion"><title>Conclusions:</title><p>Functional gastrointestinal symptoms appear to occur in a significant proportion of infants younger than 12 months and may have an impact on future health outcomes. 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Falconer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Argentine</li><li>Australie</li><li>Belgique</li><li>Brésil</li><li>France</li><li>Indonésie</li><li>Israël</li><li>Italie</li><li>Maroc</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Thaïlande</li><li>Turquie</li><li>Émirats arabes unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Région de Bruxelles-Capitale</li><li>Utrecht (province)</li><li>État de São Paulo</li></region><settlement><li>Amsterdam</li><li>Bruxelles</li><li>Londres</li><li>Paris</li><li>São Paulo</li><li>Utrecht</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Vandenplas, Yvan" sort="Vandenplas, Yvan" uniqKey="Vandenplas Y" first="Yvan" last="Vandenplas">Yvan Vandenplas</name></region></country><country name="Maroc"><noRegion><name sortKey="Abkari, Abdelhak" sort="Abkari, Abdelhak" uniqKey="Abkari A" first="Abdelhak" last="Abkari">Abdelhak Abkari</name></noRegion></country><country name="France"><noRegion><name sortKey="Bellaiche, Marc" sort="Bellaiche, Marc" uniqKey="Bellaiche M" first="Marc" last="Bellaiche">Marc Bellaiche</name></noRegion><name sortKey="Chouraqui, Jean Pierre" sort="Chouraqui, Jean Pierre" uniqKey="Chouraqui J" first="Jean Pierre" last="Chouraqui">Jean Pierre Chouraqui</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Benninga, Marc" sort="Benninga, Marc" uniqKey="Benninga M" first="Marc" last="Benninga">Marc Benninga</name></region><name sortKey="Ludwig, Thomas" sort="Ludwig, Thomas" uniqKey="Ludwig T" first="Thomas" last="Ludwig">Thomas Ludwig</name></country><country name="Turquie"><noRegion><name sortKey="Coku Ra, Fugencullu" sort="Coku Ra, Fugencullu" uniqKey="Coku Ra F" first="Fügençullu" last="Çoku Ra">Fügençullu Çoku Ra</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Harb, Tracy" sort="Harb, Tracy" uniqKey="Harb T" first="Tracy" last="Harb">Tracy Harb</name></noRegion></country><country name="Indonésie"><noRegion><name sortKey="Hegar, Badriul" sort="Hegar, Badriul" uniqKey="Hegar B" first="Badriul" last="Hegar">Badriul Hegar</name></noRegion></country><country name="Argentine"><noRegion><name sortKey="Lifschitz, Carlos" sort="Lifschitz, Carlos" uniqKey="Lifschitz C" first="Carlos" last="Lifschitz">Carlos Lifschitz</name></noRegion></country><country name="Émirats arabes unis"><noRegion><name sortKey="Miqdady, Mohamed" sort="Miqdady, Mohamed" uniqKey="Miqdady M" first="Mohamed" last="Miqdady">Mohamed Miqdady</name></noRegion></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="De Morais, Mauro Batista" sort="De Morais, Mauro Batista" uniqKey="De Morais M" first="Mauro Batista" last="De Morais">Mauro Batista De Morais</name></region></country><country name="Thaïlande"><noRegion><name sortKey="Osatakul, Seksit" sort="Osatakul, Seksit" uniqKey="Osatakul S" first="Seksit" last="Osatakul">Seksit Osatakul</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Salvatore, Silvia" sort="Salvatore, Silvia" uniqKey="Salvatore S" first="Silvia" last="Salvatore">Silvia Salvatore</name></noRegion><name sortKey="Staiano, Annamaria" sort="Staiano, Annamaria" uniqKey="Staiano A" first="Annamaria" last="Staiano">Annamaria Staiano</name></country><country name="Israël"><noRegion><name sortKey="Shamir, Raanan" sort="Shamir, Raanan" uniqKey="Shamir R" first="Raanan" last="Shamir">Raanan Shamir</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Szajewska, Hania" sort="Szajewska, Hania" uniqKey="Szajewska H" first="Hania" last="Szajewska">Hania Szajewska</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Thapar, Nikhil" sort="Thapar, Nikhil" uniqKey="Thapar N" first="Nikhil" last="Thapar">Nikhil Thapar</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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